A Dye Densitometry Analysis Method for Noninvasive Measurement of Cardiac Output Based on NIRS
LU Meng-meng1, WANG Hong-xuan2, LIU Guang-da1*, XIN Gui-jie3, YU Yong1, ZHA Yu-tong1
1. College of Instrumentation and Electrical Engineering, Jilin University, Changchun 130061, China 2. State Key Laboratory of Laser Interaction with Matter, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China 3. First Hospital, Jilin University, Changchun 130021, China
Abstract：Currently, there exist technology problems in cardiac output (CO) parameter detection clinically, such as invasive and complex operation, as well as possibility of infection and death for patients. In order to solve these problems, a noninvasive and continuous method based on NIRS for CO detection was presented. In this way, the concentration changing of indocyanine green (ICG) dye in the patient’s arterial blood was dynamically measured and analyzed, so that the CO could be noninvasively and continuously measured according to the characteristic parameters of dye densitometry curve. While the ICG dye was injected into the patient’s body by the median cubital vein, block of photoelectric pulse dye densitometry measurement system as the lower machine acquired pulse wave data and uploaded the data to upper computer. In the scheme, two specialized light sources of LED at 940 and 805 nm were used to capture the signals of sufferer’s fingertip pulse wave synchronously and successively. The CO value could then be successfully calculated through drawing complete ICG concentration variation of dye dilution and excretion process and computing mean transmission time (MTT) by upper computer. Compared with the “gold standard” method of thermodilution, the maximum relative error of this method was below 9.76%, and the mean relative error was below 4.39%. The result indicates that the method can be used as a kind of convenient operation, noninvasive and continuous solution for clinical CO measurement.
卢蒙蒙1，王红宣2，刘光达1*，辛桂杰3，于 永1，查雨彤1 . 基于近红外光谱实现心输出量无创检测的色素谱分析方法 [J]. 光谱学与光谱分析, 2013, 33(12): 3175-3179.
LU Meng-meng1, WANG Hong-xuan2, LIU Guang-da1*, XIN Gui-jie3, YU Yong1, ZHA Yu-tong1 . A Dye Densitometry Analysis Method for Noninvasive Measurement of Cardiac Output Based on NIRS . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2013, 33(12): 3175-3179.
[1] XU Jun, WANG Zhong, YU Xue-zhong, et al(徐 军，王 仲，于学忠，等). International Journal of Emergency and Critical Care Medicine(世界急危重病医学杂志), 2007, 4(1): 1697. [2] Jacquet L, Honore P, Beale R, et al. Intensive Care Medicine, 2000, 26(6): 686. [3] ZHAO Ze, WANG Ling, PAN Song-xin, et al(赵 泽，王 玲，潘颂欣，等). Chinese Journal of Biomedical Engineering(中国生物医学工程学报), 2010, 29(4): 619. [4] Goedje O, Hoeke K, Lictwarck M, et al. Critical Care Medicine, 1999, 27(11): 2407. [5] LU Sen, HUANG Xin-li, LI Xiang-cheng, et al(陆 森，黄新立，李相成，等). Chinese Journal of Bases and Clinics in General Surgery(中国普外基础与临床杂志), 2010, 17(6): 543. [6] Liu Zhe, Qu Zengqiang, Li Xiaodong, et al. Journal of Surgical Research. 2012, 175(2): 61. [7] HONG Wen-xue, ZHANG Zhong-peng, SONG Jia-lin, et al(洪文学，张仲鹏，宋佳霖，等). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2012, 32(11): 2939. [8] Gary S, David A, Jeffrey P. Biological Psychiatry, 2002, 52(7): 679. [9] Hamilton W, Remington J, et al. American Journal Physiology, 1947, 148(1): 35. [10] LIU Guang-da, GUO Wei, ZHU Ping, et al(刘光达，郭 维，朱 平，等). Laser & Infrared(激光与红外), 2009, 39(2): 169. [11] Masahiko Kanda, Shin-ichiro Niwa. Apply Optics, 1992, 31(31): 6668. [12] Jean-Michel I, Daniel P, Juji Harimoto. Anesthesiology, 2004, 100(6): 1476. [13] Marije Reekers, Mischa J, Fred Boer, et al. Anesthesia & Analgesia, 2009, 209(2): 441. [14] YANG Hao-min, LU Qi-peng, HUANG Fu-rong(杨皓旻，卢启鹏，黄富荣). Journal of Infrared and Millimeter Waves(红外与毫米波学报), 2011, 30(6): 522.
