Anti-HepG-2 Cell Properties of Rare Earth Tungstosilicic Polyoxometalates Containing 5-Fluorouracil
LIU Xia1, WANG Shuai-shuai2, FENG Chang-gen2
1. College of Science, China Agricultural University, Beijing 100193, China 2. School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China
Anti-HepG-2 Cell Properties of Rare Earth Tungstosilicic Polyoxometalates Containing 5-Fluorouracil
LIU Xia1, WANG Shuai-shuai2, FENG Chang-gen2
1. College of Science, China Agricultural University, Beijing 100193, China 2. School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China
摘要： Two novel rare earth tungstosilicic polyoxometalate containing 5-fluorouracil, K26(C4H4FN2O2)8Pr(SiW11O39)4·10H2O (FPSW) and K26(C4H4FN2O2)8Sm(SiW11O39)4·9H2O (FSSW), were synthesized and their structure were characterized by using elemental analysis, FTIR spectra, X-ray powder diffraction and TG. The antitumor activity tests of the compounds FPSW and FSSW were carried out by the methyl thiazolyl tetrazolium method in hepatocellular carcinoma cell HepG-2. The results showed that FPSW and FSSW could inhibit the HepG-2 cells in vitro significantly. The EC50 of FPSW and FSSW is 1.94×10-5 and 1.32×10-5 mol·L-1 respectively. The therapeutic index of FPSW and FSSW is 0.76 and 1.58 respectively.
Abstract：Two novel rare earth tungstosilicic polyoxometalate containing 5-fluorouracil, K26(C4H4FN2O2)8Pr(SiW11O39)4·10H2O (FPSW) and K26(C4H4FN2O2)8Sm(SiW11O39)4·9H2O (FSSW), were synthesized and their structure were characterized by using elemental analysis, FTIR spectra, X-ray powder diffraction and TG. The antitumor activity tests of the compounds FPSW and FSSW were carried out by the methyl thiazolyl tetrazolium method in hepatocellular carcinoma cell HepG-2. The results showed that FPSW and FSSW could inhibit the HepG-2 cells in vitro significantly. The EC50 of FPSW and FSSW is 1.94×10-5 and 1.32×10-5 mol·L-1 respectively. The therapeutic index of FPSW and FSSW is 0.76 and 1.58 respectively.
[1] LIU Shu-xia, WANG Chun-ling, YU Miao, et al(刘术侠，王春玲，于 淼，等). Acta Chim. Sinica(化学学报), 2005, 63(12): 1069. [2] LIU Xia, ZHAO Jun, FENG Chang-gen(刘 霞，赵 军，冯长根). Acta Chim. Sinica(化学学报), 2006, 64(19): 1988. [3] FENG Chang-gen, XIONG Yu-di, LIU Xia(冯长根，熊宇迪，刘 霞). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2010, 30(6): 1441. [4] Han Z B, Chang Y P, An H Y，et al. Chemical Research in Chinese Universities, 2003, 19(1): 15. [5] Li J, Qi Y F, Li J, et al. Journal of Coordination Chemistry, 2005, 57(15): 1309. [6] Feng C G, Wang S S, Liu X. Polish J. Chem.，2009, 83: 2079. [7] Liu X, Wang S S, Feng C G. Journal of Rare Earths, 2010, 28(6): 965. [8] Liu X, Wang S S, Feng C G. Chinese Journal of Chemistry, 2010, 28(12): 2411. [9] Jasmin C, Chermann J, Herve G, et al. Journal of the National Cancer Institute, 1974, 53(2): 469. [10] Wang X H, Liu J F, Li, J X, et al. Journal of Inorganic Biochemistry, 2003, 94(3): 279. [11] Li J, Li J, Qi Y F, et al. Chemical Journal of Chinese Universities, 2004, 25(6): 1010. [12] HAN Zheng-bo, CHANG Ya-ping, LUAN Guo-you, et al(韩正波，常雅萍，栾国有，等). Chemical Journal of Chinese Universities(高等学校化学学报)，2002, 23(9)：1660.
