A Study on Blood Flow Measurement by Diffuse Correlation Spectroscopy
LIANG Jia-ming, WANG Jing, MEI Jian-sheng, ZHANG Zhen-xi*
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Biomedical Analytical Technology and Instrumentation, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China
Abstract：Blood flow plays an important role in clinical diagnosis and treatment, and noninvasive measurement of blood flow is the expectation of both doctors and patients. In the present work, the authors employed near-infrared diffuse correlation spectroscopy (DCS) method to measure blood flow noninvasively. The relationship between speckle intensity fluctuations of the scattering light and moving blood cells in tissue was theoretically analyzed. A theoretical model and blood flow measurement system were built. Blood flow was derived by calculating the electric field temporal autocorrelation function of speckle on tissue surface. Forearm blood flow was measured in healthy human subject during cuff inflation and deflation. Experimental results show that noninvasive blood flow measurement by this system is feasible. The results also suggest that this approach can provide blood flow information throughout the whole depth profile of the tissue.
Key words：Non-invasive blood flow measurement;Diffuse correlation spectroscopy;Electric field temporal autocorrelation function
梁佳明，王 晶，梅建生，张镇西* . 基于扩散相关光谱的血流检测方法研究[J]. 光谱学与光谱分析, 2012, 32(10): 2749-2752.
LIANG Jia-ming, WANG Jing, MEI Jian-sheng, ZHANG Zhen-xi* . A Study on Blood Flow Measurement by Diffuse Correlation Spectroscopy. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2012, 32(10): 2749-2752.
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