Study on Specificity of Noninvasive Glucose Measurements Based on Two-Dimensional Correlation Mid-Infrared Spectroscopy
ZHANG Wen1, CAO Yu-zhen1*, LIU Rong2, XU Ke-xin2
1. College of Precision Instrument & Opto-electronics Engineering，Tianjin University，Tianjin 300072，China 2. State Key Laboratory of Precision Measuring Technology and Instruments，Tianjin University，Tianjin 300072，China
Abstract：Glucose specificity is the premise of spectroscopic measurements of blood glucose concentration, and it is also paramount for feasibility study of a spectral measurement method. Two-dimensional correlation spectroscopy technology is widely used in many fields such as inter-/intra-molecular reaction, material phase transition and information extraction because of its high resolution and effective Noda’s rule. In the present paper, the glucose specificity for noninvasive glucose measurements by mid-infrared spectra based on the 2D correlation spectroscopy was investigated. First, the feasibility of this method was validated by a series of in vitro experiments of glucose. Then the in vivo experiments of four volunteers were conducted and the characteristic information of glucose by mid-infrared spectra collected from human fingers was confirmed by 2D correlation spectroscopy analysis.
张 雯1，曹玉珍1*，刘 蓉2，徐可欣2 . 基于二维相关中红外光谱技术的无创血糖检测特异性研究[J]. 光谱学与光谱分析, 2012, 32(06): 1507-1511.
ZHANG Wen1, CAO Yu-zhen1*, LIU Rong2, XU Ke-xin2 . Study on Specificity of Noninvasive Glucose Measurements Based on Two-Dimensional Correlation Mid-Infrared Spectroscopy. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2012, 32(06): 1507-1511.
