Effect of Path-Length Variations on PLSR Calibration Model in Noninvasive Measurement of Blood Glucose by Mid-Infrared Spectroscopy
WANG Dong-min1, LU Qi-peng2, DING Hai-quan2, HUANG Fu-rong1*
1. Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes, Jinan University, Guangzhou 510632, China 2. State Key Laboratory of Applied Optics，Changchun Institute of Optics, Fine Mechanics and Physics Chinese Academy of Sciences, Changchun 130033, China
Abstract：In noninvasive blood glucose measurement, it is difficult to keep the contact area between skin and internal reflectance element uniform while the mid-infrared spectra of human skin are taken, and this would lead to path-length variations. To study the effect of path-length variations on PLSR calibration model, in the present paper, according to the correlation coefficients between path-lengths and glucose concentrations, two PLSR models were achieved respectively and RMSECV were 31.3 and 4.52 mg·dL-1, RMSEP were 30.3 and 98.7 mg·dL-1 for the validation set. The results show that the chance correlations between path-lengths and glucose concentrations will lead to calibration models with different accuracy and robustness. This is useful to improving the reliability of noninvasive measurement of blood glucose by mid-infrared spectroscopy.
Key words：Mid-infrared spectroscopy;Attenuated total reflection;Non-invasive blood glucose measurement;Diabetics;Partial least square regression
王动民1，卢启鹏2，丁海泉2，黄富荣1*. 中红外无创血糖测量中光程变化对PLSR模型的影响研究[J]. 光谱学与光谱分析, 2012, 32(04): 930-933.
WANG Dong-min1, LU Qi-peng2, DING Hai-quan2, HUANG Fu-rong1* . Effect of Path-Length Variations on PLSR Calibration Model in Noninvasive Measurement of Blood Glucose by Mid-Infrared Spectroscopy. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2012, 32(04): 930-933.
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