Synthesis and Spectral Characteristic of Pharmaceutical Dipfluzine Hydrochloride-Benzoic Acid Co-Crystal
YANG Cai-qin1, WANG Jing1*, ZHANG Zhen-wei2
1. School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China 2. Beijing Key Laboratory for Terahertz Spectroscopy and Imaging, Department of Physics, Capital Normal University, Beijing 100048，China
Abstract：Pharmaceutical co-crystals can improve the chemical and physical properties of active pharmaceutical ingredient (API), which is new idea and expected to provide new stable structures. Pharmaceutical co-crystals have the potential to be much more useful in pharmaceutical products than salts, solvates or hydrates, polymorphs and stoichiometric solvates (pseudo-polymorphs). In our study, dipfluzine hydrochloride-benzoic acid co-crystal was synthesized by solid co-grinding. The samples were subjected to IR, DSC, XRD, Raman and THz spectral analysis. The results indicated that dipfluzine hydrochloride-benzoic acid complex was new phase compared with the single API and CCF. THz-TDS characterization indicated that hydrogen bond formed between API and CCF, which confirmed the formation of co-crystal.
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