Study on the Estrogen Derivative Marked by CdTe Quantum Dots
ZHONG Wen-ying1, ZHANG Cui1, XU Guo-feng1, YAN Ming2, XU Dan-ke3
1. Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China 2. New Drug Screening Center of China Pharmaceutical University, Nanjing 210009, China 3. School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
Abstract：Abstract: Water-soluble CdTe quantum dots (QDs) stabilized by thioglycolic acid (TGA) with high quantum yield were synthesized. And the small biomolecule 17β-amino-estradiol was marked successfully by CdTe QDs. The analysis of UV-Vis spectroscopy, fluorescence spectroscopy, infrared spectroscopy and inverted microscope photographs showed that the surface carboxyl of CdTe quantum dots conjugated with the amino of 17β-amino-estradiol through the activation of N-hydroxysuccinimide. 17β-amino-estradiol marked by CdTe QDs successfully provided an experimental basis for new drug screening model.
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