Study on Inclusion Complexes of β-Cyclodextrin with Zopiclone
CHEN Yuan-yuan1,LIU Jia-jia1,TANG Ke-wen1,2
1. College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China 2. Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414000, China
Abstract:The inclusion complex formation of zopiclone with β-cyclodextrin was studied by using phase solubility method, and the formation constant for zopiclone -β-cyclodextrin was determined. The solubility of zopiclone and the formation constant were enhanced with the increase in β-cyclodextrin concentration and pH. The effect of temperature on the reaction was studied through thermodynamics, and the changes in entropy ΔS, enthalpy ΔH and free energy ΔG of the reaction were all negative, suggesting that the inclusion complexation is exothermic and can spontaneously occur by the balance of enthalpy driving and entropy opposing. The inclusion complex of zopiclone and β-cyclodextrin was prepared by a method of solidgrinding,Stable inclusion complex in solid state was characterized by IR spectra and DTA. Results showed that zopiclone-β-cyclodextrin conclusion complex could be formed, and β-cyclodextrin is a desirable solubilizer for zopiclone.
陈圆圆1,刘佳佳1,唐课文1,2. β-环糊精与佐匹克隆包合作用的研究[J]. 光谱学与光谱分析, 2008, 28(10): 2380-2383.
CHEN Yuan-yuan1,LIU Jia-jia1,TANG Ke-wen1,2. Study on Inclusion Complexes of β-Cyclodextrin with Zopiclone. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2008, 28(10): 2380-2383.
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