The Preparation, Characterization and Ultraviolet Photodegradation of LNG-HP-β-CD
WANG Da-wei1,2, LIU Qi3,4, LIU Ming2, LIU Xiao-hui1*
1. Key Laboratory of Weed and Rodent Biology and Management, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China 2. State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 3. Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, China 4. Key Laboratory of Dryland Farmind and Water-Saving Agriculture, Ministry of Agriculture, Beijing 100081, China
Abstract:The characteristics of levonorgestrel (LNG), low solubility and the quick degradation under ultraviolet, limited its study and application in rodent contraception. The inclusion complex of hydroxypropyl-β-cyclodextrin (HP-β-CD) with LNG was investigated in present study. The inclusion complex was prepared by solution method and characterized by ultraviolet absorption spectrum and infrared spectrum spectra. And the stability was evaluated by being exposed to ultraviolet. The authors’ results showed that the accurate and simple method of quantitative determination for LNG was established by ultraviolet spectrum, the molar ratio of the complex was 1∶1 calculated from the phase solubility diagram, the stability constant was 187.3 L·mol-1 at 25 ℃, and the formation of the inclusion complex was validated by UV-Vis and Fourier transform infrared spectroscopy. Moreover, the degradation rate of the inclusion complex was less than 5%, which was slower than the LNG monomer. The present study indicated that HP-β-CD could be formed inclusion complexes with LNG and the solubility, and stability were obviously enhanced.
王大伟1,2,刘 琪3,4,刘 明2,刘晓辉1* . LNG-HP-β-CD包合物制备、表征及其紫外稳定性研究[J]. 光谱学与光谱分析, 2011, 31(03): 808-811.
WANG Da-wei1,2, LIU Qi3,4, LIU Ming2, LIU Xiao-hui1* . The Preparation, Characterization and Ultraviolet Photodegradation of LNG-HP-β-CD . SPECTROSCOPY AND SPECTRAL ANALYSIS, 2011, 31(03): 808-811.