Synthesis, Characterization and Interaction with ct-DNA of Four Novel Secondary Amine Complexes
LIU Na1, JIA Chun-man1, ZHANG Qi1, 2*, YUAN Wen-bing1, DAI Xue-qin1, WU Jing-bo2
1. Hainan Provincial Key Lab of Fine Chem(Hainan University), Haikou 570228, China 2. College of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
Abstract：A novel ligand(L), (N,N’-bis(4-methylbenzyl)ethane-1,2-diamine), and its transition metal(Ⅱ) complex，2+·2NO-3(M=CuⅡ，CoⅡ，NiⅡ，ZnⅡ), have been synthesized and characterized by elemental analysis, IR and 1H NMR. The crystal structure of the Cu-L complex was characterized by X-ray single crystal diffraction, and the results showed a regular octahedral structure in which each metal ion is six–coordinated with four nitrogen atoms from two ligands and two oxygen atoms from two water molecules. The interaction of the complex with calf thymus DNA was investigated by UV spectroscopy and fluorescence spectroscopy, and the results suggest that the complex binds to DNA by electrostatic interaction mode. The binding constant(Cu-L, Co-L, Ni-L, Zn-L) was 1.67×103，2.5×103，1.35×103 and 9.85×102, respectively.
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