Abstract：The contents of three components in compound acetylsalicylic acid tablets were determined by dual-wavelength ratio spectrometry. According to the feature of the spectra, 213, 227, 245 and 265 nm were chosen as the determining wavelengths. It is shown that for the three components good linear correlations exist for acetylsalicylic acid (5-20 μg·mL-1), phenacetin (2-10 μg·mL-1), and caffeine (2-20 μg·mL-1). The average recoveries were 100.03%, 100.23% and 99.96% respectively. The results were consistent with those obtained by the standard method of Health Ministry(P＞0.05). The method is simple and practical with fewer determination wavelengths and powerful spectral resolution, and can be performed on a lower level instrument, as well as be easily spreaded for application.
Key words：Dual-wavelength ratio spectrometry;Acetylsalicylic acid;Phenacetin;Caffeine
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