Synthesis of Polymeric Drug Nanomicrospheres Containing Probenecid
LI Qing-hai1，2，WU Zheng-cui1*，SUN Yu1，SHEN Liang-jun1
1. College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000，China 2. Department of Biochemistry，Anhui Engineering University of Technology and Science, Wuhu 241000，China
Abstract：Nonsteroidal antiinflammatory drug, probenecid, was covalently linked with 2-hydroxyethyl methacrylate (HEMA). The drug-linked HEMA(abbreviated as HP) can be copolymerized with methy methacrylate (MMA) to obtain polymeric drug nanomicrospheres in ethanol／water system. Polymers were characterized with 1H-NMR, FTIR, GPC and TEM. The results showed that probenecid was linked with HEMA by ester bond, the microspheres were composed of copolymer of HP and MMA, whose statistical average diameters were (90±5)nm, containing 47.4% HP，and drug content was high.
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