Achievement of the Noninvasive Measurement for Human Blood Glucose with NIR Diffusion Reflectance Spectrum Method
ZHANG Hong-yan1, DING Dong2, SONG Li-qiang3, GU Lin-na1, YANG Peng1, TANG Yu-guo1
1. Changchun Institute of Optics and Fine Mechanic and Physics, Chinese Academy of Sciences, Changchun 130021, China 2. Jilin University，Changchun 130012, China 3. Yunnan Normal University, Kunming 650092, China
Abstract：The noninvasive measurement of human blood glucose was achieved with NIR diffusion reflectance spectrum method. The thumb fingertip NIR diffusion reflectance spectra of six different age healthy volunteers were collected using Nexus-870 and its NIR fiber port smart accessory. The test was implemented with changing the blood glucose concentration for the limosis and satiation of every volunteer. The calibration model was set up using PLS method with the smoothing, baseline correction and first derivatives pretreatment spectrum in the 7 500-8 500 cm-1 region for single volunteer, the same age combination and that of different age. When the spectrum was obtained, the actual blood glucose value of every spectrum sample was demarcated using ultraviolet spectrophotometer. The correlation between the calibration value and true value for single volunteer is better than that for the combination of volunteers, the correlative coefficients are all over 0.904 71, RMSECs are all less than 0.171.
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