Time-Resolved Optoacoustic Technique and Its Applications to Noninvasive Monitoring of Biological Tissue
SU Yi-xiong1, WANG Rui-kang1, 2*, XU Ke-xin3, ZHANG Fan1, YAO Jian-quan1
1.Key Laboratory of Laser and Optoelectronic Information Science and Technology, Ministry of Education, College of Precision Instruments and Opto-electronics, Tianjin University，Tianjin 300072, China 2.Biophotonics Laboratory, Institute of Bioscience and Technology, Cranfield University at Silsoe, Beds, MK45 4DT, UK 3.State Key Laboratory of Precision Measuring Technology and Instrumentations, College of Precision Instruments and Opto-electronics, Tianjin University，Tianjin 300072, China
Abstract：Time-resolved optoacoustic technique offers a new ingredient in noninvasive monitoring of biological tissues.Due to the heterogeneous property of biotissue, different level of optical energy depositions generates different strength of the acoustic signal across the tissue.This makes it possible to probe the functional information tomographically inside the biological tissue.It becomes increasingly attractive as a hybrid non-invasive monitoring technique because it takes the advantages of high contrast feature delivered by the optical techniques and high penetration depth and resolution offered by the acoustical techniques.After a brief introduction of its theory, this paper reviews the state-of-the-art time-resolved optoacoustic methods that have been successfully applied in biomedicine, with a concentration on analytical monitoring and tomography.
苏翼雄1，王瑞康1，2*， 徐可欣3，张 帆1，姚建铨1 . 时域光声谱技术及其在生物组织检测中的应用[J]. 光谱学与光谱分析, 2005, 25(08): 1176-1179.
SU Yi-xiong1, WANG Rui-kang1, 2*, XU Ke-xin3, ZHANG Fan1, YAO Jian-quan1 . Time-Resolved Optoacoustic Technique and Its Applications to Noninvasive Monitoring of Biological Tissue. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2005, 25(08): 1176-1179.
[1] MacKenzie H A, Christison G B, Hodgson P, et al.Sensors and Actuators, B, 1993, 11: 213. [2] Quan K M, Christison G B, MacKenzie H A，et al.Phys.Med.and Biol.，1993, 38: 1911. [3] Christison G B, MacKenzie H A.Med.and Biol.Engineering and Computing，1993，31： 284. [4] Duncan A, Hannigan J, Freeborn S S，et al.A Portable Non-Invasive Blood Glucose Monitor.8th Int.Conf.Solid State Sensors and Actuators and Eurosensors Ⅸ, Stockholm, Sweden, 1995，455. [5] Esenaliev R O, Larina I V, Larin K V，et al.Applied Optics，2002, 41(22): 4722. [6] Petrov Y Y, Prough D S, Hilbert D，et al.Two-Wavelength Optoacoustic Technique for Accurate, Noninvasive, and Continuous Measurement of Blood Oxygenation.Proceedings of the Second Joint EMBS/BMES Conference，Houston, TX, USA., 2002，2287. [7] Xu M，Wang L H.IEEE Transactions on Medical Imaging，2002, 21(7): 814. [8] Xueding Wang, Yongjiang Pang, Geng Ku，et al.Nature Biotechnology，2003, 21(7): 803. [9] Wang X, Pang Y, Ku G, et al.Optics Letters，2003, 28(19): 1739. [10] Kstli K P, Frauchiger D, Niederhauser J J, et al.IEEE Journal on Selected Topics in Quantum Electronics，2001, 7(6): 918. [11] Kstli K P, Frenz M, Weber H P，et al.Appl.Opt.，2001, 40(22): 3800. [12] Karabutov A A, Podymova N B, Letokhov V S.Appl.Phys.B，1996, 63: 545. [13] Bednov A A, Savateeva E V, Oraevsky A A.SPIE Proceedings, 2003, 4960: 21. [14] Andreev V G, Karabutov A A, Solomatin S V，et al.SPIE Proceedings，2000, 3916: 36. [15] Bell A G.American Journal of Sciences, Third Series.1880, ⅩⅩ(118): 305. [16] QIAN Sheng-you, XING Da(钱盛友，邢 达).Acta Laser Biology Sinica(激光生物学报)，2000, 9(3): 228. [17] Spanner G，Niessner R.Opto.and Laser Europe，1996, 32: 31. [18] Rosencwaig A.SPIE Proceedings，2000, 3916: 2. [19] Fainchtein R, Stoyanov B J, Murphy J C，et al.SPIE Proceedings，2000, 3916: 19. [20] Kruger R A, Kiser Jr W L, Miller K D, et al.SPIE Proceedings，2000，3916: 150. [21] Kruger R A, Kiser Jr W L, Reinecke D R, et al.Molecular Imaging，2003, 2(2): 113. [22] Kruger R A, Kiser Jr W L, Reinecke D R, et al.Medical Physics，2003, 30(5): 856.
