Abstract：IR-online detector, React IRTM 4000, was used to monitor the synthesis of N,N-diphenyl urea from urea and aniline. The concentration changes of the reaction components were obtained according to the characteristic IR absorbance changes of the reactants (urea and aniline) at 1 420 and 1 270 cm-1 respectively, the intermediate product (monophenylurea) at 1 339 cm-1 as well as the product (N,N-diphenyl urea) at 1 312 cm-1. In the present study, the result showed that the synthesis of N,N-Diphenyl urea was carried out by two steps. Firstly, the intermediate product monophenylurea was synthesized from urea and aniline, and then N,N-diphenyl urea was obtained by the reaction of monophenylurea with aniline. It was also shown that the IR-online detector was a fast, simple and exact technique to optimize the reaction time and so the reaction course could be easily controlled. The result of IR-online spectrometry was approved by offline reference high performance liquid chromatography (HPLC) method. As a result, the IR-online spectrometry was superior to HPLC method since it was a nondestructive method without the need to sample the reaction medium.
姚洁，康涛，胡晓佳，陈彤*,雷永诚，王公应* . 红外光谱在线监控对二苯脲合成反应进程的研究[J]. 光谱学与光谱分析, 2009, 29(07): 1781-1783.
YAO Jie, KANG Tao, HU Xiao-jia, CHEN Tong*, LEI Yong-cheng, WANG Gong-ying* . Monitoring the Synthesis of N,N-Diphenyl Urea by IR-Online. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2009, 29(07): 1781-1783.
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