甲状腺癌组织的傅里叶变换拉曼光谱研究

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摘要：利用傅里叶变换拉曼光谱仪得到了甲状腺癌和甲状腺正常组织样品的拉曼光谱，这2种组织样本的拉曼特征峰主要出现在400～3 500 cm^-1的波长范围内。在甲状腺正常组织的拉曼光谱中位于503和758 cm^-1处有两个特征峰，758 cm^-1处峰指认为苯环的环振动，503 cm^-1处的拉曼峰经分析初步指认为C—Ⅰ伸缩振动，这2个特征峰在甲状腺癌的拉曼光谱中均消失。在甲状腺正常组织的拉曼光谱中位于3 062和1 003 cm^-1处酪氨酸的特征峰，在甲状腺癌组织的拉曼光谱中，这2处峰的相对强度明显降低。因此，拉曼光谱法有望成为甲状腺癌诊断的有效方法。

关键词：甲状腺癌;拉曼光谱;诊断

Abstract：The normal and malignant tissues from hypothyroid were investigated by FT-Raman spectroscopy. The results show that two characteristic Raman spectral peaks of normal tissues appeared at 503 and 758 cm^-1 (corresponding to the extension vibration of C—Ⅰ band and the vibration of benzene rings respectively) in the range of 400-3 500 cm^-1. The two peaks disappeared at malignant tissues. The intensity of the characteristic vibration peaks of normal tissues appearing at 3 062 and 1 003 cm^-1 corresponding to tyrosine weakened in malignant tissues. Thus, FT-Raman spectroscopy is a potential method in the diagnosis of hypothyroid cancer.

Key words：Hypothyroid cancer;Raman spectra;Diagnosis

收稿日期: 2005-12-09 修订日期: 2006-03-20

中图分类号:

O657.3

通讯作者: 周光明

引用本文:

李蓉¹,周光明^2*,彭红军²,邓永利² . 甲状腺癌组织的傅里叶变换拉曼光谱研究[J]. 光谱学与光谱分析, 2006, 26(10): 1868-1870.
LI Rong¹,ZHOU Guang-ming^2*,PENG Hong-jun²,DENG Yong-li² . FT-Raman Spectroscopic Investigation on Hypothyroid Cancer. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(10): 1868-1870.

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https://www.gpxygpfx.com/CN/Y2006/V26/I10/1868

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