Abstract：The charge transfer interactions of Azithromycin and 7,7,8,8-tetracyanoquinodimethane (TCNQ) or chloranilic acid(CL) were investigated by spectrophotometry. The apparent molar absorptivity of TCNQ complex is 2.7×104 L·mol-1·cm-1at 743 nm，and 5.0×104 L·mol-1·cm-1at 842 nm;and that of CL complex is 2.4×103 L·mol-1·cm-1. Beers law is obeyed in the concentration range of 0-30 mg·L-1 for TCNQ method, and 5-225 mg·L-1 for CL method. The relative standard deviations of the two methods are 1.0% and 1.4 % (n=6), respectively. The composition of complex of Azithromycin with 7,7,8,8-tetracyanoquinodimethane or chloranilic acid is 1∶2. This proposed method has been applied to the determination of Azithromycin in tablets with satisfactory results.
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