Studies on the Interaction of the Metal Complex of Hydrazide of Podophyllic Acid with DNA
WANG Ping-hong1, ZHANG Qi1*, WANG Liu-fang2, SONG Yu-min3, QU Jian-qiang2, LIU Ying-qian2
1. Province Key Laboratory of Refined Chemistry, Hainan University, Haikou 570228, China 2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China 3. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China
Abstract：The interaction between the metal complex of hydrazide of podophyllic acid and calf thymus (CT) DNA was studied by using absorption spectra, fluorescence spectra and DNA heat denaturation. It was found that the intensity of the maximal absorption peaks from absorption spectra is weakened in the presence of the metal complex of hydrazide of podophyllic acid compared with that in the absence of the metal complex. All the experimental results show that the intercalation mode was proved to exist between HDPP-Ni complexes and CT DNA.
Key words：Metal complex;Ethidium bromide;Calf thymus DNA
王平红1,张 岐1*,王流芳2,宋玉民3,曲建强2,刘营前2 . 鬼臼酰肼镍(Ⅱ)金属配合物与DNA的相互作用[J]. 光谱学与光谱分析, 2006, 26(05): 941-943.
WANG Ping-hong1, ZHANG Qi1*, WANG Liu-fang2, SONG Yu-min3, QU Jian-qiang2, LIU Ying-qian2 . Studies on the Interaction of the Metal Complex of Hydrazide of Podophyllic Acid with DNA. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(05): 941-943.
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