Abstract：In the present study, the electron transfer between Etoposide (VP-16) and GMP or DNA was investigated using pulse radiolysis and circular dichroism technology. The electron transfer between VP-16 and GMP was found, and the reaction rate constant was determined as 3.16×107 L·mol-1·s-1 by pulse radiolysis. The authors found the interaction of VP-16 and DNA using the technology of circular dichroism. This study has provided theoretical reference for further study on the anti-tumor mechanism of VP-16.
张蕤1,史钧1，2,汪世龙1*,孙晓宇1,张超杰1 . VP-16与DNA分子间电子转移的光谱学研究[J]. 光谱学与光谱分析, 2006, 26(11): 1977-1980.
ZHANG Rui1, SHI Jun1，2,WANG Shi-long1*, SUN Xiao-yu1, ZHANG Chao-jie1 . Studies on the Electron Transfer between Etoposide (VP-16) and DNA. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2006, 26(11): 1977-1980.
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