Abstract：Surface-enhanced Raman scattering spectrum is a very effective tool for detecting the interface character and interaction of molecules and expounding molecular configuration and adsorption behavior on the surface. It is becoming one of the best techniques to study interface effect, widely used in studying orientation and behavior of adsorption molecules on the surface and the feature of interface, as well as analysis of interphase tropism, configuration and conformation of biologic molecules. SERS technique is becoming a strong hand in surface science and electrochemistry, and widely used in trace analysis and even single molecule detecting (SM-SERS), medical chemistry, environmental sciences, biologic and medical systems, nano-materials and sensors. There is even conjunction application of SERS with other techniques. The present paper emphasized to summarize the headway of application research of SERS in the late years，along with the introduction of some work in our lab, especially, as a new field, on Fullerenes thin film and carbon nano-tube materials.
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