1. Key Laboratory of Optoelectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, China 2. British Columbia Cancer Research Centre, Vancouver, BC, Canada, V5Z IL3
摘要： 在分析皮肤组织结构、皮肤荧光光谱与反射光谱产生机制的基础上，改变皮肤真皮上、下血管丛的血液含量，依此建立相应的皮肤六层光学模型，并进行 Monte Carlo模拟计算。结果表明：皮肤荧光光谱与反射光谱均可反映皮肤组织内血液含量的变化;皮肤的真皮上层血管丛的血液含量对光谱强度的影响大，深部血管丛血液含量对光谱强度的影响小;荧光光谱和反射光谱可用于探测或分析皮肤组织中血液含量的变化，特别可能用于真皮上层血管血液病变的皮肤疾病的病患程度及治疗效果的检测。
关键词：皮肤血液含量;荧光光谱;反射光谱;Monte Carlo模拟
Abstract：Based on the analysis of skin structure, and the production mechanism of fluorescence and reflectance spectra, six-layer optical models for skin of different blood content in both upper blood plexus and deep blood plexus were developed, and Monte Carlo simulation was made. The result shows that (1) Both fluorescence and reflectance spectra could reflect the change of blood content in skin tissue; (2) The impact of blood content in upper blood plexus on skin spectra intensity is large, while the impact of blood content in deep blood plexus on skin spectra intensity is small; (3) Fluorescence and reflectance spectra could be used to detect or analyze change of blood content in skin tissue, especially to test the treatment and tune of dermatosis with plexus or blood pathological changes in upper dermis.
Key words：Skin blood content;Fluorescence spectra;Reflectance spectra;Monte Carlo simulation
[1] GU Ying, JIANG Lan, ZHAO Xiu-mei，et al(顾 瑛，姜 澜，赵秀梅，等) . Chinese J. Laser Med. Surg.(中国激光医学杂志), 1995, 4(3): 151. [2] YU Chang-qing, LIU Jie, DOU Xiao-ming，et al(于常青，刘 杰，窦晓鸣，等). Spectroscopy and Spectral Analysis(光谱学与光谱分析)，2003, 23(6): 1150. [3] WU J, et al. Applied Optics, 1993, 32(19): 3585. [4] Zeng Haishan, MacAulay Calum, McLean David I，et al. Journal of Photochemistry and Photobiology B: Biology, 1997, 38: 234. [5] Wang Lihong, Jacques Steven L. MCML-Monte Carlo Simulation of Multi-layered Turbid Media. Laser Biology Research Laboratory, University of Texas M. D, Anderson Cancer Center Houston, TX 77030, 1993. [6] Zeng Haishan. Monte Carlo Simulation of Multi-layered Turbid Media On Fluorescence Escape Process. MCML Program of the Univ. of Texas M. D. Anderson Cancer Center, 1992. [7] Zeng Haishan, MacAulay Calum, Palcic Branko，et al. SPIE，1994, 2135: 94.
