Synthesis, Spectroscopic Characterization, Thermogravimetric and Biological Activity Evaluation of Te(Ⅳ), Se(Ⅳ), V(Ⅲ), Nb(Ⅴ), Ta(Ⅴ) Complexes With Indole-3-Acetic Acid Plant Hormone Ligand
Jehan Y. Al-Humaidi1, Foziah A. Al-Saif1, Dalal N. Binjawhar1, Hanan A. Bakhsh1，Moamen S. Refat2*
1. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
2. Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah 21974, Taif, Saudi Arabia
Synthesis, Spectroscopic Characterization, Thermogravimetric and Biological Activity Evaluation of Te(Ⅳ), Se(Ⅳ), V(Ⅲ), Nb(Ⅴ), Ta(Ⅴ) Complexes With Indole-3-Acetic Acid Plant Hormone Ligand
Jehan Y. Al-Humaidi1, Foziah A. Al-Saif1, Dalal N. Binjawhar1, Hanan A. Bakhsh1，Moamen S. Refat2*
1. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
2. Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah 21974, Taif, Saudi Arabia
摘要： Te(Ⅳ), Se(Ⅳ), V(Ⅲ), Nb(Ⅴ) and Ta(Ⅴ) complexes of indole-3-acetic acid (IAAH) ligand were synthesized, characterized by elemental analysis and various spectroscopic techniques like, IR, 1H-NMR, X-ray powder diffraction, UV-Visible, thermogravimetry analysis, magnetic measurements, molar conductance and surface morphology using SEM. All the synthesized complexes of IAAH ligand have 1∶2 stoichiometry of the types [Te(IAA)2(NH3)2]·2Cl (Ⅰ), [Se(IAA)2(NH3)2]·2Cl (Ⅱ), [V(IAA)2(NH3)(Cl)] (Ⅲ), [Nb(IAA)2(Cl)3] (Ⅳ), and [Ta(IAA)2(Cl)3] (Ⅴ). Spectral analysis indicates octahedral geometry for the Te(Ⅳ), Se(Ⅳ) and V(Ⅲ) complexes, whereas both Nb(Ⅴ) and Ta(Ⅴ) have a seven-coordination. The bonding sites are the oxygen atoms of carboxylate group for the deprotonated indole-3-acetic acid (IAA) ligand. The thermogravimetry analysis studies gave evidence for the presence of other coordinated molecules (Cl or NH3) in the composition of IAA complexes, which were further supported by IR and micro analytical measurements. The higher molar conductance data of tellurium and selenium (Ⅳ) complexes reveal that these chelates are electrolytes, while low conductivity values for the vanadium(Ⅲ), niobium and tantalum(Ⅴ) chelates indicated a non-electrolytes. To test the antibacterial property of the five complexes in this study, four bacterial strains Klebsiella (G-), Escherichia coli (G-), Staphylococcus aureus (G+) and Staphylococcus epidermidis (G+) were used in the investigation. The effects of the five complexes in the cytotoxicity of Caco-2 and Mcf-7 human cancer cell lines were studied Neutral red uptake assay for the estimation of cell viability/cytotoxicity protocol.
关键词：Indole-3-acetic acid; chelation; IR; Metal ions; TEM; Antimicrobial test
Abstract：Te(Ⅳ), Se(Ⅳ), V(Ⅲ), Nb(Ⅴ) and Ta(Ⅴ) complexes of indole-3-acetic acid (IAAH) ligand were synthesized, characterized by elemental analysis and various spectroscopic techniques like, IR, 1H-NMR, X-ray powder diffraction, UV-Visible, thermogravimetry analysis, magnetic measurements, molar conductance and surface morphology using SEM. All the synthesized complexes of IAAH ligand have 1∶2 stoichiometry of the types [Te(IAA)2(NH3)2]·2Cl (Ⅰ), [Se(IAA)2(NH3)2]·2Cl (Ⅱ), [V(IAA)2(NH3)(Cl)] (Ⅲ), [Nb(IAA)2(Cl)3] (Ⅳ), and [Ta(IAA)2(Cl)3] (Ⅴ). Spectral analysis indicates octahedral geometry for the Te(Ⅳ), Se(Ⅳ) and V(Ⅲ) complexes, whereas both Nb(Ⅴ) and Ta(Ⅴ) have a seven-coordination. The bonding sites are the oxygen atoms of carboxylate group for the deprotonated indole-3-acetic acid (IAA) ligand. The thermogravimetry analysis studies gave evidence for the presence of other coordinated molecules (Cl or NH3) in the composition of IAA complexes, which were further supported by IR and micro analytical measurements. The higher molar conductance data of tellurium and selenium (Ⅳ) complexes reveal that these chelates are electrolytes, while low conductivity values for the vanadium(Ⅲ), niobium and tantalum(Ⅴ) chelates indicated a non-electrolytes. To test the antibacterial property of the five complexes in this study, four bacterial strains Klebsiella (G-), Escherichia coli (G-), Staphylococcus aureus (G+) and Staphylococcus epidermidis (G+) were used in the investigation. The effects of the five complexes in the cytotoxicity of Caco-2 and Mcf-7 human cancer cell lines were studied Neutral red uptake assay for the estimation of cell viability/cytotoxicity protocol.
Key words：Indole-3-acetic acid; chelation; IR; Metal ions; TEM; Antimicrobial test
基金资助: the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University, through the Research Groups Program Grant no. (RGP-1440-0001)(2)
通讯作者:
Moamen S. Refat
E-mail: msrefat@yahoo.com
引用本文:
Jehan Y. Al-Humaidi, Foziah A. Al-Saif, Dalal N. Binjawhar, Hanan A. Bakhsh，Moamen S. Refat. Synthesis, Spectroscopic Characterization, Thermogravimetric and Biological Activity Evaluation of Te(Ⅳ), Se(Ⅳ), V(Ⅲ), Nb(Ⅴ), Ta(Ⅴ) Complexes With Indole-3-Acetic Acid Plant Hormone Ligand[J]. 光谱学与光谱分析, 2021, 41(02): 658-664.
Jehan Y. Al-Humaidi, Foziah A. Al-Saif, Dalal N. Binjawhar, Hanan A. Bakhsh，Moamen S. Refat. Synthesis, Spectroscopic Characterization, Thermogravimetric and Biological Activity Evaluation of Te(Ⅳ), Se(Ⅳ), V(Ⅲ), Nb(Ⅴ), Ta(Ⅴ) Complexes With Indole-3-Acetic Acid Plant Hormone Ligand. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2021, 41(02): 658-664.
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