Synthesis and Spectroscopic Characterizations of New Mercury(Ⅱ), Cerium(Ⅲ), and Thorium(Ⅳ) Captopril Drug Complexes
Samy M. El-Megharbel1,2*，Moamen S. Refat1,3
1. Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
2. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
3. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt
Synthesis and Spectroscopic Characterizations of New Mercury(Ⅱ), Cerium(Ⅲ), and Thorium(Ⅳ) Captopril Drug Complexes
Samy M. El-Megharbel1,2*，Moamen S. Refat1,3
1. Department of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
2. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
3. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt
摘要： In this article, three types of metal ions with different oxidation state as mercury(Ⅱ), cerium(Ⅲ) thorium(Ⅳ) have been reacted with captopril drug (CAP). The isolated solid complexes were explained using elemental analysis, conductance measurements, infrared and 1H-NMR spectroscopy as well as the thermo gravimetric (TG/DTG) analysis. The micro analytical and spectroscopic results for all CAP complexes were agreement with the speculated structures. The stoichiometry for divalent Hg2+, trivalent Ce3+ and tetravalent Th4+ metal ions with CAP ligand was established with 1∶2 (Mn+:CAP) molar ratio. The qualitative analysis showed that in case of the mercury(Ⅱ) complex, the chloride ions didn’t involved in the complexity, suggesting formula [Hg(CAP)2] in neutral form. However, regarding both Ce(Ⅲ) and Th(Ⅳ) complexes as [Ce(CAP)2(NO3)]·3H2O and [Th(CAP)2(NO3)2(H2O)]·3H2O formulas, the nitrate group is existed inside the coordination sphere. The infrared analysis data proved that CAP drug act as a bidentate ligand with the metal ions of Ce(Ⅲ) and Th(Ⅳ) through oxygen carbonyl group CO and oxygen of the deprotonated carboxylic COOH group, while for the Hg(Ⅱ) complex, the CAP acts as a bidentate ligand through oxygen of CO group and sulfur atom of the deprotonated —SH group. Thorium(Ⅵ) complex has a nine-coordinate geometry, while Hg(Ⅱ) and Ce(Ⅲ) have a four and six-coordination behaviors respectively. The 1H-NMR data of the CAP compound has a singlet sharp signal at 1.90 ppm due to the proton of —SH group, this peak absent in the spectrum of the Hg(Ⅱ) CAP complex upon the deprotonated of thiol group.
关键词：Captopril drug; Metal ions; FTIR; 1H-NMR
Abstract：In this article, three types of metal ions with different oxidation state as mercury(Ⅱ), cerium(Ⅲ) thorium(Ⅳ) have been reacted with captopril drug (CAP). The isolated solid complexes were explained using elemental analysis, conductance measurements, infrared and 1H-NMR spectroscopy as well as the thermo gravimetric (TG/DTG) analysis. The micro analytical and spectroscopic results for all CAP complexes were agreement with the speculated structures. The stoichiometry for divalent Hg2+, trivalent Ce3+ and tetravalent Th4+ metal ions with CAP ligand was established with 1∶2 (Mn+:CAP) molar ratio. The qualitative analysis showed that in case of the mercury(Ⅱ) complex, the chloride ions didn’t involved in the complexity, suggesting formula [Hg(CAP)2] in neutral form. However, regarding both Ce(Ⅲ) and Th(Ⅳ) complexes as [Ce(CAP)2(NO3)]·3H2O and [Th(CAP)2(NO3)2(H2O)]·3H2O formulas, the nitrate group is existed inside the coordination sphere. The infrared analysis data proved that CAP drug act as a bidentate ligand with the metal ions of Ce(Ⅲ) and Th(Ⅳ) through oxygen carbonyl group CO and oxygen of the deprotonated carboxylic COOH group, while for the Hg(Ⅱ) complex, the CAP acts as a bidentate ligand through oxygen of CO group and sulfur atom of the deprotonated —SH group. Thorium(Ⅵ) complex has a nine-coordinate geometry, while Hg(Ⅱ) and Ce(Ⅲ) have a four and six-coordination behaviors respectively. The 1H-NMR data of the CAP compound has a singlet sharp signal at 1.90 ppm due to the proton of —SH group, this peak absent in the spectrum of the Hg(Ⅱ) CAP complex upon the deprotonated of thiol group.
Key words：Captopril drug; Metal ions; FTIR; 1H-NMR
基金资助: Taif University Researches Supporting Project number (TURSP-2020/15), Taif University, Taif, Saudi Arabia
通讯作者:
Samy M. El-Megharbel
E-mail: samyelmegharbel@yahoo.com
引用本文:
Samy M. El-Megharbel，Moamen S. Refat. Synthesis and Spectroscopic Characterizations of New Mercury(Ⅱ), Cerium(Ⅲ), and Thorium(Ⅳ) Captopril Drug Complexes[J]. 光谱学与光谱分析, 2020, 40(11): 3649-3652.
Samy M. El-Megharbel，Moamen S. Refat. Synthesis and Spectroscopic Characterizations of New Mercury(Ⅱ), Cerium(Ⅲ), and Thorium(Ⅳ) Captopril Drug Complexes. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(11): 3649-3652.
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