Synthesis and Spectroscopic Characterizations of the Mono- and Bimolecular Iron(Ⅲ) Complexes by the Interaction With Tris Buffer in Neutralized Media: Biological and Morphological Investigations
Jehan Y Al-Humaidi1, Foziah A Al-Saif1, Dalal N Binjawhar1, Salha E Alotaibi1，Moamen S Refat2,3*
1. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
2. Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah 21974, Taif, Saudi Arabia
3. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt
Synthesis and Spectroscopic Characterizations of the Mono- and Bimolecular Iron(Ⅲ) Complexes by the Interaction With Tris Buffer in Neutralized Media: Biological and Morphological Investigations
Jehan Y Al-Humaidi1, Foziah A Al-Saif1, Dalal N Binjawhar1, Salha E Alotaibi1，Moamen S Refat2,3*
1. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
2. Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah 21974, Taif, Saudi Arabia
3. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt
摘要： The reaction of iron(Ⅲ) anions, FeCl3 and Fe2(SO4)3 with tris(hydroxymethyl) aminomethane (Tris) in a 1∶2 molar ratio affords the new coordination compounds NH4[Fe2(Tris)2(H2O)4(SO4)] (Ⅰ) and NH4[Fe(Tris)2(H2O)2] (Ⅱ). These compounds were characterized by elemental analysis, and their molecular structures were determined by spectroscopic methods (infrared and electronic spectra), magnetic susceptibility, and molar conductivity measurements, and further corroborated by thermo gravimetric analysis and its differential (TGA/DrTGA). According to the experimental data, the complexes can be characterized in the solid state as mono- and binuclear, with a distorted octahedral stereochemistry. The distorted octahedral stereochemistry adopted by the complexes was confirmed by the magnetic susceptibility measurement of NH4[Fe2(Tris)2(H2O)4(SO4)], which consists of a six-coordinate iron atoms in a distorted octahedral environment constructed from four O atoms (two Tris molecules), two O atoms from the loosely associated SO4 coordinated ligand, and O, N of second Tris molecule with occupying by four oxygen atoms of coordinated water molecules. Regarding, NH4[Fe(Tris)2(H2O)2] complex the mono iron atom is surrounded by six oxygen atoms as four by two Tris molecules and two coordinated water molecules in axial form. Antibacterial and anticancer activities of the complexes were studied and the complexes were screened against bacteria, colorectal adenocarcinoma (Caco-2) and breast cancer (Mcf-7) cell lines.
关键词：Tris; Iron aninons; Coordination; FTIR; Morphology; Biological activity
Abstract：The reaction of iron(Ⅲ) anions, FeCl3 and Fe2(SO4)3 with tris(hydroxymethyl) aminomethane (Tris) in a 1∶2 molar ratio affords the new coordination compounds NH4[Fe2(Tris)2(H2O)4(SO4)] (Ⅰ) and NH4[Fe(Tris)2(H2O)2] (Ⅱ). These compounds were characterized by elemental analysis, and their molecular structures were determined by spectroscopic methods (infrared and electronic spectra), magnetic susceptibility, and molar conductivity measurements, and further corroborated by thermo gravimetric analysis and its differential (TGA/DrTGA). According to the experimental data, the complexes can be characterized in the solid state as mono- and binuclear, with a distorted octahedral stereochemistry. The distorted octahedral stereochemistry adopted by the complexes was confirmed by the magnetic susceptibility measurement of NH4[Fe2(Tris)2(H2O)4(SO4)], which consists of a six-coordinate iron atoms in a distorted octahedral environment constructed from four O atoms (two Tris molecules), two O atoms from the loosely associated SO4 coordinated ligand, and O, N of second Tris molecule with occupying by four oxygen atoms of coordinated water molecules. Regarding, NH4[Fe(Tris)2(H2O)2] complex the mono iron atom is surrounded by six oxygen atoms as four by two Tris molecules and two coordinated water molecules in axial form. Antibacterial and anticancer activities of the complexes were studied and the complexes were screened against bacteria, colorectal adenocarcinoma (Caco-2) and breast cancer (Mcf-7) cell lines.
Key words：Tris; Iron aninons; Coordination; FTIR; Morphology; Biological activity
基金资助: The Deanship of Scientific Research at Princess Nourah bint Abdulrahman University, through the Research Groups Program (RGP-1440-0001)(2)
通讯作者:
Moamen S Refat
E-mail: msrefat@yahoo.com
引用本文:
Jehan Y Al-Humaidi, Foziah A Al-Saif, Dalal N Binjawhar, Salha E Alotaibi，Moamen S Refat. Synthesis and Spectroscopic Characterizations of the Mono- and Bimolecular Iron(Ⅲ) Complexes by the Interaction With Tris Buffer in Neutralized Media: Biological and Morphological Investigations[J]. 光谱学与光谱分析, 2020, 40(10): 3309-3314.
Jehan Y Al-Humaidi, Foziah A Al-Saif, Dalal N Binjawhar, Salha E Alotaibi，Moamen S Refat. Synthesis and Spectroscopic Characterizations of the Mono- and Bimolecular Iron(Ⅲ) Complexes by the Interaction With Tris Buffer in Neutralized Media: Biological and Morphological Investigations. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(10): 3309-3314.
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