Chelation Assignments of GaⅢ, GeⅣ and SiⅣ Metal Ions With Pipemidic Acid Antibiotic Drug: Synthesis, Spectroscopic Characterizations and Biological Studies
Abeer A El-Habeeb
Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
Chelation Assignments of GaⅢ, GeⅣ and SiⅣ Metal Ions With Pipemidic Acid Antibiotic Drug: Synthesis, Spectroscopic Characterizations and Biological Studies
Abeer A El-Habeeb
Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia
摘要: Pipemidic acid is one of an efficient quinolone antibacterial drug. Thecomplexitybetween pipemidic acid “Hpipc” withgallium(Ⅲ), germanium(Ⅳ) and silicon(Ⅳ) afforded three molecular formulas of [Ga(pipc)2(H2O)(Cl)]·4H2O, 1, [Ge(pipc)2(Cl)2]·4H2O, 2 and[Si(pipc)2(Cl)2]·4H2O, 3 complexes. These three new complexes were characterized based on elemental analysis, conductance, FTIR, UV-Vis, 1HNMR and XRD spectroscopy. The pipc chelate exhibits O, O coordinated through the carbonyl (C═O) and carboxylato (COO) of both oxygen atoms. Six coordinate geometry was proposed regarding complexes of 2 and 3, so the axial position was occupied by two coordinated chlorideatoms. In vitro, the antibacterial, antifungal, and anti-cancer assessments concerning the synthesized pipc complexes were scanned. These complexes have an excellent anti-microbial activity.
关键词:Pipemidic; Metal ions; Chelation; FTIR; XRD; Biological activity
Abstract:Pipemidic acid is one of an efficient quinolone antibacterial drug. Thecomplexitybetween pipemidic acid “Hpipc” withgallium(Ⅲ), germanium(Ⅳ) and silicon(Ⅳ) afforded three molecular formulas of [Ga(pipc)2(H2O)(Cl)]·4H2O, 1, [Ge(pipc)2(Cl)2]·4H2O, 2 and[Si(pipc)2(Cl)2]·4H2O, 3 complexes. These three new complexes were characterized based on elemental analysis, conductance, FTIR, UV-Vis, 1HNMR and XRD spectroscopy. The pipc chelate exhibits O, O coordinated through the carbonyl (C═O) and carboxylato (COO) of both oxygen atoms. Six coordinate geometry was proposed regarding complexes of 2 and 3, so the axial position was occupied by two coordinated chlorideatoms. In vitro, the antibacterial, antifungal, and anti-cancer assessments concerning the synthesized pipc complexes were scanned. These complexes have an excellent anti-microbial activity.
Key words:Pipemidic; Metal ions; Chelation; FTIR; XRD; Biological activity
Abeer A El-Habeeb. Chelation Assignments of GaⅢ, GeⅣ and SiⅣ Metal Ions With Pipemidic Acid Antibiotic Drug: Synthesis, Spectroscopic Characterizations and Biological Studies[J]. 光谱学与光谱分析, 2020, 40(10): 3303-3308.
Abeer A El-Habeeb. Chelation Assignments of GaⅢ, GeⅣ and SiⅣ Metal Ions With Pipemidic Acid Antibiotic Drug: Synthesis, Spectroscopic Characterizations and Biological Studies. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2020, 40(10): 3303-3308.
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