Study on the Effect of He-N2 Ratio in Mixed Carrier Gas on Separation of VOC Aliasing Peaks in FAIMS
SHI Hai-xia1, XU Qing1, 2, WANG Han2, 3, LIU You-jiang2, LI Shan2, HU Jun2, 3, LI Yue1, 2*, CHEN Chi-lai2*
1. College of Automotive and Transportation Engineering, Hefei University of Technology, Hefei 230009, China
2. State Key Laboratory of Sensing Technology, Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei 230031, China
3. Department of Automation, University of Science and Technology of China, Hefei 230027, China
Abstract：Carrier gas mixing as one of the most important methods to improve the separation ability of high Field Asymmetric waveform Ion Mobility Spectrometry (FAIMS) has been widely used in the field of bio macromolecule mass spectrometry, while there is a lack of some research in environmental small molecules. In this paper, five typical volatile organic compounds (VOCs), including o-xylene, isobutanol, n-hexane, acetic acid and acetone, were chosen to study the effect of N2-He mixing ratio on the peak position, resolution and ion pass rate of monomers and dimer ion. The results showed that with the increase of the proportion of He in the carrier gas of FAIMS, the peak position of the monomer and dimer ion in five VOCs shifts, and the peak of the monomer and the dimer were different, and the monomer peak shift increased first and then decreased, while the dimer peak position shift increased gradually. With the increase of the percentage of He, the resolution of FAIMS for aliasing peaks of five VOCs gradually increased and tended to saturate at last, where the saturated helium ratio was: 20%, 30%, 10%, 40% and 20%, respectively. In addition, with the increase of the percentage of helium, the signal intensity of o-xylene, isobutanol, n-hexane and acetone had no obvious change, while that of acetic acid decreased significantly. This study provided a feasible method for improving the separation ability of FAIMS and validating the effectiveness of Blanc’s law under high electric field applied in the field of small molecules.
Key words：High-field asymmetric waveform ion mobility spectrometry; Resolution; Volatile organic compounds; Carrier gas mixing
石海峡，徐 青，王 晗，刘友江，李 山，胡 俊，李 跃，陈池来. 混合载气高场不对称波形离子迁移谱中He-N2比例对挥发性有机物混叠峰分离的影响研究[J]. 光谱学与光谱分析, 2019, 39(09): 2713-2718.
SHI Hai-xia, XU Qing, WANG Han, LIU You-jiang, LI Shan, HU Jun, LI Yue, CHEN Chi-lai. Study on the Effect of He-N2 Ratio in Mixed Carrier Gas on Separation of VOC Aliasing Peaks in FAIMS. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2019, 39(09): 2713-2718.
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