The Study of Fast Localization Method of Anomaly Block in Tissue Based on Differential Optical Density
WANG Hui-quan1, 2, REN Li-na1, ZHAO Zhe1, 2, WANG Jin-hai1, 2*, CHEN Hong-li1, 2
1. School of Electronics and Information Engineering, Tianjin Polytechnic University, Tianjin 300387, China
2. Tianjin Photoelectric Detection Technology and Systems Key Laboratory, Tianjin 300387, China
Abstract：The position of the source-detector (S-D) relative to the anomaly had an important influence on the detection effect when the detection of the anomaly in tissues was non-invasive based on near-infrared spectroscopy. In this study, a Single-Source Multi-Detectors structure was designed in order to realize the rapid localization of anomaly within the organization. This method was for finite element analysis of optical density distribution for different horizontal positions, depths and diameters of anomaly. Then calculated the difference in optical density between the detectors. The simulation results showed that the horizontal position of the anomaly in the tissue could be quickly located according to the differential optical density difference curves formed by the multiple detectors. The Gaussian fitting feature of these curves has a strong correlation with the horizontal positions, depths and diameters of the anomaly. Through the differential optical density difference curves, rapid localization could be achieved within the region of interest in the organization. It provides an important reference for the sources and detectors location in terms of tumor detection, brain function optical imaging and other fields using near infrared spectroscopy, which can improve its detection accuracy.
王慧泉, 任丽娜, 赵 喆, 王金海, 陈洪丽. 基于差分光密度差异的组织内异质体的快速定位方法[J]. 光谱学与光谱分析, 2018, 38(11): 3362-3367.
WANG Hui-quan, REN Li-na, ZHAO Zhe, WANG Jin-hai, CHEN Hong-li. The Study of Fast Localization Method of Anomaly Block in Tissue Based on Differential Optical Density. SPECTROSCOPY AND SPECTRAL ANALYSIS, 2018, 38(11): 3362-3367.
[1] Tao Z, Dang X, Huang X, et al. Biomaterials, 2017, 134: 202.
[2] Nosrati R, Vesely K, Schweizer T A, et al. Biomedical Optics Express, 2016, 7(4): 1323.
[3] Schober P, Bossers S M, Schwarte L A. BioMed Research International, 2017: 1846830.
[4] Robertson C S, Gopinath S P, Chance B. Journal of Neurotrauma, 1995, 12(4): 591.
[5] Wu J B, Shi C, Chu G C, et al. Biomaterials, 2015, 67(10): 1.
[6] Tian H, Li M, Wang Y, et al. Infrared Physics & Technology, 2017，86：98.
[7] LI Gang, FU Zhi-gang, GUAN Yang, et al(李 钢，付志刚，关 洋，等). Spectroscopy and Spectral Analysis(光谱学与光谱分析), 2016，36(9)：3020.
[8] Dai X, Zhang T, Yang H, et al. Journal of Biophotonics, 2018，11(3).
[9] Lee J J, Segar D J, Morrison J F, et al. Journal of Neurosurgery, 2018，128(1)：236.
[10] Di S L, Wabnitz H, Pifferi A, et al. Review of Scientific Instruments, 2016, 87(3): 035118.
[11] Wang J, Liu D, Sun J, et al. International Symposium on Infrared Technology and Application，2016, 10157.
[12] Dehghani H, Eames M E, Yalavarthy P K, et al. Communications in Numerical Methods in Engineering, 2009, 25(6): 711.
[13] Hannukainen A, Harhanen L, Hyvnen N, et al. Inverse Problems, 2016, 32(1): 015008.
[14] Wrobel M S, Popov A P, Bykov A V, et al. Journal of Innovative Optical Health Sciences, 2015, 8(3): 1541005.
